Miao X Y
Second Affiliated Hospital, Human Medical University, Changsha.
Zhonghua Wai Ke Za Zhi. 1990 Apr;28(4):228-30, 253-4.
The changes of the plasma thromboxane B2 (TXB2) and 6-keto-PGF1 alpha, the stable metabolites of TXA2 and PGI2, respectively and their effects on platelet counts, platelet aggregation and hypotension were studied in patients with AOSC. The results showed that the plasma TXB2, 6-keto-PGF1 alpha and 6-keto-PGF1 alpha/TXB2 ratios in these patients were markedly increased, however, the platelet counts markedly decreased and platelet aggregation inhibited significantly. After operation, they recovered to normal gradually. There were negative correlation between TXB2 with platelet count and 6-keto-PGF1 alpha with platelet aggregation, as well as both TXB2 and 6-keto-PGF1 alpha with blood pressure. TXA2 was an important factor which lead to platelet decrement and take part in the pathological course of disseminated intravascular coagulation (DIC) and multiple organ failure (MOF), but PGI2 might play an important role in improving microcirculation and preventing DIC and MOF through the inhibition of platelet aggregation.
对急性重症胆管炎（AOSC）患者血浆血栓素B2（TXB2）和6-酮-前列腺素F1α（分别为血栓素A2（TXA2）和前列环素（PGI2）的稳定代谢产物）的变化及其对血小板计数、血小板聚集和低血压的影响进行了研究。结果显示，这些患者的血浆TXB2、6-酮-前列腺素F1α及6-酮-前列腺素F1α/TXB2比值显著升高，然而，血小板计数显著降低，血小板聚集受到明显抑制。术后，它们逐渐恢复正常。TXB2与血小板计数、6-酮-前列腺素F1α与血小板聚集以及TXB2和6-酮-前列腺素F1α与血压之间均呈负相关。TXA2是导致血小板减少的重要因素，并参与弥散性血管内凝血（DIC）和多器官功能衰竭（MOF）的病理过程，但PGI2可能通过抑制血小板聚集在改善微循环及预防DIC和MOF方面发挥重要作用。
