Department of Nutrition, Clinica Las Condes.
Cardiovacular Prevention Department. Sanatorio Finochietto.
J Atheroscler Thromb. 2019 Mar 1;26(3):207-215. doi: 10.5551/jat.RV17030. Epub 2019 Jan 19.
Statins are the main treatment for hypercholesterolemia and the cornerstone of atherosclerotic cardiovascular disease prevention. Many patients taking statins report muscle-related symptoms, one of the most important causes of statin treatment discontinuation, which is associated with an increased risk of cardiovascular events. Therefore, it is important to identify patients who are truly statin intolerant to avoid unnecessary discontinuation of this beneficial treatment. Some studies indicate that not all muscle complaints are caused by statins, and most patients can tolerate a statin upon re-challenge, down-titration of dose, or switching to another statin. In this paper, we review the definitions of statin intolerance and approaches to reducing cardiovascular risk among individuals reporting statin-associated muscle symptoms.
他汀类药物是治疗高胆固醇血症的主要药物，也是预防动脉粥样硬化性心血管疾病的基石。许多服用他汀类药物的患者报告有肌肉相关症状，这是导致他汀类药物治疗中断的最重要原因之一，与心血管事件风险增加有关。因此，识别真正对他汀类药物不耐受的患者非常重要，以避免不必要地停止这种有益的治疗。一些研究表明，并非所有的肌肉投诉都是由他汀类药物引起的，大多数患者可以在重新接受他汀类药物治疗、减少剂量或改用另一种他汀类药物时耐受。在本文中，我们回顾了他汀类药物不耐受的定义以及在报告与他汀类药物相关的肌肉症状的个体中降低心血管风险的方法。
