Miernik Sebastian, Matusiewicz Agata, Olesińska Marzena
Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
Biomedicines. 2024 Apr 30;12(5):987. doi: 10.3390/biomedicines12050987.
Drug-induced myopathies are a common cause of muscle pain, and the range of drugs that can cause muscle side effects is constantly expanding. In this article, the authors comprehensively discuss the diagnostic and therapeutic process in patients with myalgia, and present the spectrum of drug-induced myopathies. The review provides a detailed analysis of the literature on the incidence of myopathy during treatment with hypolipemic drugs, beta-blockers, amiodarone, colchicine, glucocorticosteroids, antimalarials, cyclosporine, zidovudine, and checkpoint inhibitors, a group of drugs increasingly used in the treatment of malignancies. The article considers the clinical course of the different types of myopathies, their pathogenesis, histopathological features, and treatment methods of these disorders. The aim of this paper is to gather from the latest available literature up-to-date information on the course, pathophysiology, and therapeutic options of drug-induced myopathies, to systematize the knowledge of drug-induced myopathies and to draw the attention of internists to the fact that these clinical issues are an important therapeutic problem.
药物性肌病是肌肉疼痛的常见原因，可导致肌肉副作用的药物范围在不断扩大。在本文中，作者全面讨论了肌痛患者的诊断和治疗过程，并介绍了药物性肌病的范围。该综述对有关降血脂药物、β受体阻滞剂、胺碘酮、秋水仙碱、糖皮质激素、抗疟药、环孢素、齐多夫定以及检查点抑制剂治疗期间肌病发生率的文献进行了详细分析，检查点抑制剂是一组越来越多地用于治疗恶性肿瘤的药物。本文考虑了不同类型肌病的临床病程、发病机制、组织病理学特征以及这些疾病的治疗方法。本文的目的是从最新的文献中收集有关药物性肌病的病程、病理生理学和治疗选择的最新信息，将药物性肌病的知识系统化，并引起内科医生对这些临床问题是一个重要治疗问题这一事实的关注。
