Brune K
Department of Pharmacology, University of Erlangen-Nürnberg, Federal Republic of Germany.
Agents Actions Suppl. 1988;25:9-19.
All non-opioid analgesics are believed to act via inhibition of cyclo-oxygenase. With respect to their inhibitory potency towards the enzyme, these drugs differ not only from most non-steroidal anti-inflammatory drugs but also among themselves. The differences appear to be of some therapeutic relevance. They explain why many non-steroidal anti-inflammatory drugs are unsuitable for over-the-counter (OTC) use and why the OTC drugs have different profiles of effects and side effects. In addition, the suitability of non-opioid analgesics in everyday practice is widely determined by their pharmacokinetic parameters. These parameters are here compiled for aspirin, paracetamol (acetaminophen), ibuprofen, and metamizol (dipyrone), then compared, and finally evaluated as to their therapeutic implications.
所有非阿片类镇痛药据信都是通过抑制环氧化酶发挥作用的。就其对该酶的抑制效力而言，这些药物不仅与大多数非甾体抗炎药不同，而且彼此之间也存在差异。这些差异似乎具有一定的治疗相关性。它们解释了为什么许多非甾体抗炎药不适合非处方药（OTC）使用，以及为什么非处方药具有不同的疗效和副作用特征。此外，非阿片类镇痛药在日常实践中的适用性很大程度上取决于其药代动力学参数。此处汇总了阿司匹林、对乙酰氨基酚、布洛芬和安乃近的这些参数，然后进行比较，最后对其治疗意义进行评估。
