Faculty of Natural and Applied Sciences, St John's University of Tanzania, Dodoma, Tanzania.
Department of Chemistry, University of Dar es Salaam, Dar es Salaam, Tanzania.
Nat Prod Res. 2020 Nov;34(22):3163-3168. doi: 10.1080/14786419.2018.1553168. Epub 2019 Jan 19.
Characterisation of a novel discolornolide () isolated from a first time investigation of is described. Other 6 known compounds, karatavin (), -acetylanonaine (), quercetin-3--arabinose (), stigmasterol (, a mixture of stigmasterol and β-sitosterol () and octahydro-5-isopropyl-3-methyl-2-methyleneazulene-8,8-diol () isolated are also reported. The structures were established by spectroscopic methods. Citotoxicities and antimicrobial activities of the compounds and crude extracts are also reported whereby compound showed in antifungal activity against and at concentrations of 0.13 and 0.17 mg/ml with zones of inhibitions of 7.0 and 5.5 mm respectively. The compound also showed cyitotoxic activity in the brine shrimp test with LC of 5.88 μg/ml. - Compound exhibited antibacterial activity against and . The compound also exhibited cytotoxic activities in the brine shrimp test with LC of 24.73 μg/mL. The crude extracts exhibited varying citotoxic and in antimicrobial activities.
描述了从首次调查中分离得到的一种新型 discolornolide () 的特征。还报道了其他 6 种已知化合物，karatavin ()、-acetylanonaine ()、槲皮素-3--阿拉伯糖苷 (), stigmasterol (, 混合的 stigmasterol 和 β-sitosterol () 和 octahydro-5-isopropyl-3-methyl-2-methyleneazulene-8,8-diol ()。结构通过光谱方法确定。还报告了化合物和粗提取物的细胞毒性和抗菌活性，其中化合物在 0.13 和 0.17mg/ml 的浓度下对 和 表现出抗真菌活性，抑菌环分别为 7.0 和 5.5mm。该化合物在卤虫试验中也表现出细胞毒性活性，LC 为 5.88μg/ml。-化合物对 和 表现出抗菌活性。该化合物在卤虫试验中也表现出细胞毒性活性，LC 为 24.73μg/ml。粗提取物表现出不同的细胞毒性和在 抗菌活性。
