Bozkurt Guzel Cagla, Oyardi Ozlem, B Savage Paul
a Faculty of Pharmacy, Department of Pharmaceutical Microbiology , Istanbul University , Istanbul , Turkey.
b Department of Chemistry and Biochemistry , Brigham Young University , Provo , UT , USA.
J Chemother. 2018 Oct-Dec;30(6-8):332-337. doi: 10.1080/1120009X.2018.1534567.
Ceragenins, a novel family of antibiotics, are cationic derivatives of cholic acid and display broad-spectrum antimicrobial activities. Multiple ceragenins have been synthesized and studied, and most published data are with ceragenin CSA-13. This study aimed to investigate the in vitro antimicrobial properties of second-generation ceragenins, CSA-142 and CSA-192, and compare them to CSA-13. The antimicrobial activities of CSA-13, CSA-142 and CSA-192 were studied against 20 strains of Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. Time-kill curve methods were performed to determine the bactericidal and fungicidal activities of the ceragenins against three strains of each microorganism. Overall, CSA-13 showed the lowest MIC values, but also CSA-142 and CSA-192 had good activities against tested microorganisms. The killing curves showed that ceragenins generally had bactericidal and fungicidal effects. The bactericidal and fungicidal behaviours of CSA-142 and CSA-192 may make them good alternative agents to CSA-13.
杀菌素是一类新型抗生素，是胆酸的阳离子衍生物，具有广谱抗菌活性。多种杀菌素已被合成并研究，大多数已发表的数据都与杀菌素CSA - 13有关。本研究旨在探究第二代杀菌素CSA - 142和CSA - 192的体外抗菌特性，并将它们与CSA - 13进行比较。研究了CSA - 13、CSA - 142和CSA - 192对20株大肠杆菌、鲍曼不动杆菌、铜绿假单胞菌、金黄色葡萄球菌和白色念珠菌的抗菌活性。采用时间 - 杀菌曲线法测定杀菌素对每种微生物的三株菌株的杀菌和杀真菌活性。总体而言，CSA - 13显示出最低的最低抑菌浓度值，但CSA - 142和CSA - 192对受试微生物也有良好的活性。杀菌曲线表明，杀菌素通常具有杀菌和杀真菌作用。CSA - 142和CSA - 192的杀菌和杀真菌行为可能使它们成为CSA - 13的良好替代药物。
