College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan Province 425000, China.
Hunan Key Laboratory of Green Chemistry and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou, 412007, China.
Recent Pat Anticancer Drug Discov. 2019;14(1):70-84. doi: 10.2174/1574892814666190119165157.
Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positive bacteria, fungi, and tumor cells.
An overview of the state of play with regard to the research trend of antimicrobial peptides in recent years and the situation of targeting tumor cells, and to make statistical analysis of the patents related to anticancer peptides published in recent years, is important both from toxicological and medical tumor therapy point of view.
Based on the Science Citation Index Expanded version, the Derwent Innovation Index and Innography as data sources, the relevant literature and patents concerning antimicrobial peptides and anticancer peptides were analyzed through the Thomson Data Analyzer. Results of toxicologic and pharmacologic studies that brought to the development of patents for methods to novel tumor drugs were analyzed and sub-divided according to the specific synthesis of anticancer peptides.
The literature and patent search data show that the research and development of global antimicrobial peptides and anticancer peptides has been in an incremental mode. Growing patent evidence indicate that bioinformatics technology is a valuable strategy to modify, synthesize or recombine existing antimicrobial peptides to obtain tumor drugs with high activity, low toxicity and multiple targets.
These findings may have important clinical implications for cancer treatment, especially in patients with conditions that are not currently treatable by other drugs, or that are resistant to existing cancer drugs.
抗菌肽在先天免疫系统中发挥着重要作用。具有广谱抗菌活性的抗菌肽可以快速治疗和杀死各种靶标，包括革兰氏阴性菌、革兰氏阳性菌、真菌和肿瘤细胞。
从毒理学和医学肿瘤治疗的角度来看，综述近年来抗菌肽的研究趋势和靶向肿瘤细胞的情况，并对近年来发表的抗癌肽相关专利进行统计分析，这一点非常重要。
基于科学引文索引扩展版、德温特创新索引和 Innography 作为数据源，通过 Thomson Data Analyzer 对有关抗菌肽和抗癌肽的相关文献和专利进行分析。根据抗癌肽的具体合成，对带来新型肿瘤药物方法专利开发的毒理学和药理学研究结果进行分析和细分。
文献和专利搜索数据显示，全球抗菌肽和抗癌肽的研究与开发一直处于递增模式。越来越多的专利证据表明，生物信息学技术是一种有价值的策略，可以修饰、合成或重组现有的抗菌肽，以获得具有高活性、低毒性和多靶点的肿瘤药物。
这些发现可能对癌症治疗具有重要的临床意义，特别是在目前无法用其他药物治疗的患者或对现有癌症药物耐药的患者中。
