Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Hunan University, Changsha 410082, China.
Chem Commun (Camb). 2019 Feb 5;55(12):1758-1761. doi: 10.1039/c9cc00211a.
A bioluminescent probe, BP-HNO, which exhibits a turn-on response to nitroxyl with high sensitivity and selectivity, is reported for the first time in this work. BP-HNO is free from the interference of biological autofluorescence to afford a high signal-to-noise ratio for bioimaging, and was successfully applied to imaging nitroxyl in live cells and mice.
本工作首次报道了一种生物发光探针 BP-HNO，它对亚硝酸根具有高灵敏度和选择性的开启响应。BP-HNO 不受生物自发荧光的干扰，为生物成像提供了高信噪比，并成功应用于活细胞和小鼠内亚硝酸根的成像。
