RSNO、HSNO 和 HNO 的特定反应及其在荧光探针设计中的应用。
Specific Reactions of RSNO, HSNO, and HNO and Their Applications in the Design of Fluorescent Probes.
机构信息
Department of Chemistry, Brown University, Providence, RI, 02912, USA.
出版信息
Chemistry. 2020 Sep 10;26(51):11673-11683. doi: 10.1002/chem.202001885. Epub 2020 Jul 20.
Abstract
Nitric oxide (NO)-derived species play essential roles in regulating cellular responses. Among these species, S-nitrosothiols (including RSNO and HSNO) and nitroxyl (HNO) are especially interesting. Owing to their high reactivity and short survival time, the detection of these molecules in biological settings can be challenging. In this regard, much effort has been invested in exploring novel reactions of RSNO/HSNO/HNO and applying these reactions to develop fluorescence probes. Herein, reported specific reactions of RSNO/HSNO/HNO are summarized and strategies used in the design of fluorescent probes are illustrated. The properties and potential problems of representative probes are also discussed.
摘要
一氧化氮（NO）衍生的物质在调节细胞反应中发挥着重要作用。在这些物质中，S-亚硝基硫醇（包括 RSNO 和 HSNO）和硝酰阴离子（HNO）尤其有趣。由于它们的高反应性和短的存活时间，在生物环境中检测这些分子具有挑战性。在这方面，人们投入了大量精力来探索 RSNO/HSNO/HNO 的新反应，并将这些反应应用于开发荧光探针。本文总结了 RSNO/HSNO/HNO 的特定反应，并说明了荧光探针设计中使用的策略。还讨论了代表性探针的性质和潜在问题。
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