Masopust Jiri, Tvaroh Aleš, Pavelek Zbyšek, Valis Martin
Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, and University Hospital Hradec Kralove, Czech Republic.
Department of Neurology, Krajska zdravotni a.s. - Nemocnice Teplice o.z., Czech Republic.
Neuro Endocrinol Lett. 2018 Dec;39(5):351-354.
We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Further development demonstrated that the patient probably suffered from a paraneoplastic form of the disease, although the presence of an underlying tumour was not detected by the available imaging methods at the time of diagnosis. The case is a rarity since the disease usually affects females, and only 5% of adult male patients have a paraneoplastic aetiology.
我们报告了一例抗N-甲基-D-天冬氨酸受体（NMDAR）抗体阳性的脑炎患者。抗NMDAR脑炎是一种相对罕见的自身免疫性疾病。在我们的患者中，抗NMDAR脑炎的诊断直到该病首次出现症状几个月后才得以确立。进一步的检查表明，该患者可能患有副肿瘤性抗NMDAR脑炎，尽管在诊断时现有的影像学方法未检测到潜在肿瘤的存在。该病例较为罕见，因为这种疾病通常影响女性，只有5%的成年男性患者有副肿瘤性病因。
