GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC 1408 Inserm Vaccinology, Hopital Nord, CHU Saint-Etienne, France.
Neurology Department, Hopital Nord, CHU Saint-Etienne, France.
Clin Immunol. 2016 May;166-167:96-9. doi: 10.1016/j.clim.2016.03.011. Epub 2016 Mar 25.
The association of small cell lung cancer with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is rare. We report a 62 year old patient who developed psychiatric disorders followed by epilepsy, movement disorders, mutism and hypoventilation. Flair weighted brain MRI sequences showed diffuse high signals in the limbic system. Anti-NMDAR antibodies were detected in the serum and CSF. The patient's IgGs reacted with the patient's own tumor cells and with 2 out of 4 small cell lung cancers of patients without neurological syndrome.
小细胞肺癌与抗 N-甲基-D-天冬氨酸受体（NMDAR）脑炎的关联很少见。我们报告了一例 62 岁患者，其先出现精神障碍，继之癫痫发作、运动障碍、缄默和通气不足。FLAIR 加权脑 MRI 序列显示边缘系统弥漫性高信号。血清和 CSF 中检测到抗 NMDAR 抗体。患者的 IgG 与自身肿瘤细胞以及 4 例无神经综合征的小细胞肺癌中的 2 例发生反应。
