Verrecchia Luca, Glad Karin, Frisk Rebecka, Duan Maoli
a Department of Clinical Sciences Intervention and Technology, Division of Ear, Nose and Throat Diseases , Karolinska Institutet, Karolinska University Hospital , Stockholm , Sweden.
b Department of Clinical Sciences Intervention and Technology, Division of Audiology , Karolinska Institutet , Stockholm , Sweden.
Acta Otolaryngol. 2019 Jan;139(1):11-17. doi: 10.1080/00016489.2018.1536297. Epub 2019 Jan 21.
Vestibular-evoked myogenic potential (VEMP) is commonly conducted with air-conducted (AC) stimuli whose intensity may exceed the prudential levels of acoustic exposure in susceptible subjects.
To determine the diagnostic accuracy of AC VEMP for superior canal dehiscence syndrome (SCDS) at lowered acoustic stimulation levels.
VEMP was tested in 10 SCDS patients and in 10 age/sex matched control subjects. VEMP were recorded on cervical muscles (cVEMP) and extraocular muscles (oVEMP) in response to short AC tone bursts at 500, 1000 and 2000 Hz delivered at 80 dB nHL (103 dB peSPL). Parameters of interest were the response amplitude and the frequency tuning.
VEMP evoked by AC stimuli at safe acoustic stimulation levels did effectively separate SCDS patients from healthy controls. The separation was optimal at all the frequencies tested, however 500 Hz resulted the best VEMP tuning frequency, especially at oVEMP.
Lowering the AC stimulation to the levels compatible with testing of patients susceptible to acoustic exposure didn't affect the VEMP diagnostic properties for SCDS.
SCDS may be screened by VEMP even among subjects susceptible for acoustic exposure.
前庭诱发肌源性电位（VEMP）通常采用气导（AC）刺激进行检测，其强度可能超过易感受试者的谨慎声学暴露水平。
确定在降低声学刺激水平时，AC VEMP对上半规管裂综合征（SCDS）的诊断准确性。
对10例SCDS患者和10例年龄/性别匹配的对照受试者进行VEMP检测。记录颈部肌肉（cVEMP）和眼外肌（oVEMP）对500、1000和2000Hz的短AC纯音猝发刺激（80dB nHL，103dB peSPL）的反应。感兴趣的参数为反应幅度和频率调谐。
在安全声学刺激水平下，AC刺激诱发的VEMP能有效区分SCDS患者和健康对照。在所有测试频率下，这种区分都是最佳的，然而500Hz是最佳的VEMP调谐频率，尤其是在oVEMP方面。
将AC刺激降低到与声学暴露易感患者检测相适应的水平，并不影响VEMP对SCDS的诊断特性。
即使在声学暴露易感受试者中，也可通过VEMP筛查SCDS。
