γδ TCR 配体：解决一个 5 亿年历史之谜的探索。
γδ TCR ligands: the quest to solve a 500-million-year-old mystery.
机构信息
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Institute of Immunology and Immunotherapy, Cancer Immunology and Immunotherapy Centre, Cancer Research UK Birmingham Centre, University of Birmingham, Birmingham, UK.
出版信息
Nat Immunol. 2019 Feb;20(2):121-128. doi: 10.1038/s41590-018-0304-y. Epub 2019 Jan 21.
γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success.
γδ T 细胞在大多数脊椎动物的进化过程中被保留为一个谱系，能够以独特的方式对免疫挑战做出反应，并且越来越受到治疗的关注。然而，一个核心谜团仍然存在：γδ T 细胞抗原受体识别的配体的身份。在这里，我们讨论回答这个问题所面临的固有挑战，以及最近的研究提供的新机会，以及该领域可能判断成功的标准。
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