Department of Pesticide Science, College of Plant Protection, Shenyang Agricultural University, Shenyang, 110866, PR China; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China.
Beijing Bayi School, No. 29 Suzhou Street, Haidian District, Beijing, 100080, PR China.
Regul Toxicol Pharmacol. 2019 Apr;103:150-157. doi: 10.1016/j.yrtph.2019.01.025. Epub 2019 Jan 18.
To preliminarily study the law of natural dissipation and the relation to human health of a new insecticide (afidopyropen), the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method and a UHPLC-MS/MS system were used to extract and detect the afidopyropen and its metabolite (M440I007) from cucumber and nectarine. The limits of quantitation (LOQs) of both target compounds in two matrixes were reduced to 0.0001 mg/kg. Dissipative dynamics experiments indicated that afidopyropen residue dissipation is more consistent with a two-compartment kinetic model than a first-order kinetic model whether in cucumber or nectarine. The half-lives were less than 1.1 and 2.0 days in the distribution phase and up to 9.9 and 27.7 days in the elimination phase in cucumber and nectarine, respectively. The correlation coefficients were 0.9620, 0.9391, and 0.9923 for cucumber and 0.9676 and 0.9985 for nectarine from different locations. M440I007 initially increased rapidly, reached a maximum at 2 days, and then decreased gradually over time. Finally, dietary risk assessment indicated that the mixed residues of afidopyropen and M440I007 at the recommended dosage would not cause health concerns in population.
为初步研究新型杀虫剂（氟吡呋喃酮）的自然消解规律及其与人体健康的关系，采用 QuEChERS（Quick，Easy，Cheap，Effective，Rugged and Safe）方法和 UHPLC-MS/MS 系统，从黄瓜和油桃中提取并检测氟吡呋喃酮及其代谢物（M440I007）。两种基质中目标化合物的定量限（LOQs）均降低至 0.0001 mg/kg。消解动态实验表明，氟吡呋喃酮在黄瓜和油桃中的残留消解均更符合双室动力学模型，而不是一级动力学模型。在分布相，半衰期小于 1.1 和 2.0 天，在消除相，半衰期分别达到 9.9 和 27.7 天。不同地点的黄瓜和油桃的相关系数分别为 0.9620、0.9391 和 0.9923，0.9676 和 0.9985。M440I007 最初迅速增加，在第 2 天达到最大值，然后随时间逐渐减少。最后，膳食风险评估表明，推荐剂量下氟吡呋喃酮和 M440I007 的混合残留不会对人群健康造成危害。
