Barbarino A, De Marinis L, Mancini A, Calabrò F, Massari M, D'Amico C, Sambo P, Tofani A, Folli G
Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.
Diabetes Res. 1988 May;8(1):21-4.
The present study was designed to investigate the influence of a calcium antagonist (verapamil) on the two phases of insulin release. The present results confirmed our previous studies and in vitro data, showing that the first phase insulin release is not inhibited by a calcium antagonist and strongly indicated that glucose stimulated insulin secretion has two phases of release: (1) the first phase of release, which is independent from extracellular calcium; (2) the second phase of release, which was inhibited by calcium antagonists, is dependent from calcium uptake from an extracellular source.
本研究旨在探讨钙拮抗剂（维拉帕米）对胰岛素释放两个阶段的影响。目前的结果证实了我们之前的研究及体外实验数据，表明钙拮抗剂不会抑制胰岛素释放的第一阶段，并有力地表明葡萄糖刺激的胰岛素分泌有两个释放阶段：（1）第一阶段释放，其独立于细胞外钙；（2）第二阶段释放，其受钙拮抗剂抑制，依赖于从细胞外来源摄取钙。
