Honda M, Izumi Y, Hatano M
2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Nihon Naibunpi Gakkai Zasshi. 1988 Aug 20;64(8):623-35. doi: 10.1507/endocrine1927.64.8_623.
The influence of a Mg-deficient diet on blood pressure and various hormonal systems was examined in Wistar rats (WR) and spontaneously hypertensive rats (SHR). The WR and SHR were individually divided into 2 groups. The Mg-deficient diet was given to one group, and a Mg-containing diet was given to the other group for 3 weeks. During this experimental period, the body weight, blood pressure, urine volume, blood and urinary electrolytes, plasma steroid hormones, plasma renin activity (PRA), and urinary hormones [kinin, prostaglandin E2 (PGE2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and noradrenaline] were examined. Although no significant difference in body weight was observed between the Mg-deficient and Mg-containing diet groups in either the WR or SHR (because the experiments were performed in a pair-fed fashion in both kinds of rat), the blood pressure was increased in the Mg-containing diet group but was unchanged in the Mg-deficient diet group. As regards changes in electrolytes, a decreased urinary excretion of Mg and significantly increased urinary excretion of P were observed in the Mg-deficient diet group in both the WR and SHR. Furthermore, decreased levels of serum Mg and P and increased levels of serum Ca were also noted. In the WR group, the urinary excretion of noradrenaline was significantly increased in the Mg-deficient diet group as compared to the Mg-containing diet group. However, the change was reversed in the SHR group. The plasma steroid hormones and PRA were both significantly low in the Mg-deficient diet group in both the WR and SHR. The urinary excretions of PGE2, 6-keto-PGF1 alpha, and kinin showed no significant differences between the two diet groups. The above results indicate that blood pressure is not affected by the Mg-deficient diet in either the WR or SHR, and the possible participation of the sympathetic nervous system in the mechanism of control of blood pressure may differ somewhat between the WR and SHR. In addition, Mg ion was found to play an important role in the biosynthesis of renin and steroid hormones but to have no such significant role in the urinary excretions of kinin, PGE2, and 6-keto-PGF1 alpha.
在Wistar大鼠（WR）和自发性高血压大鼠（SHR）中研究了缺镁饮食对血压和各种激素系统的影响。将WR和SHR分别分为2组。一组给予缺镁饮食，另一组给予含镁饮食，持续3周。在这个实验期间，检测了体重、血压、尿量、血液和尿液电解质、血浆类固醇激素、血浆肾素活性（PRA）以及尿液激素[激肽、前列腺素E2（PGE2）、6-酮-前列腺素F1α（6-酮-PGF1α）和去甲肾上腺素]。尽管在WR或SHR中，缺镁饮食组和含镁饮食组之间的体重没有显著差异（因为两种大鼠的实验都是以配对喂养的方式进行的），但含镁饮食组的血压升高，而缺镁饮食组的血压没有变化。关于电解质的变化，在WR和SHR的缺镁饮食组中均观察到尿镁排泄减少，尿磷排泄显著增加。此外，还注意到血清镁和磷水平降低，血清钙水平升高。在WR组中，缺镁饮食组的去甲肾上腺素尿排泄量比含镁饮食组显著增加。然而，在SHR组中这种变化则相反。在WR和SHR中，缺镁饮食组的血浆类固醇激素和PRA均显著降低。两种饮食组之间PGE2、6-酮-PGF1α和激肽的尿排泄量没有显著差异。上述结果表明，缺镁饮食对WR或SHR的血压均无影响，并且交感神经系统在血压控制机制中的可能参与在WR和SHR之间可能略有不同。此外，发现镁离子在肾素和类固醇激素的生物合成中起重要作用，但在激肽、PGE2和6-酮-PGF1α的尿排泄中没有如此显著的作用。
