Honda M, Manabe R, Minato M, Watanabe M, Fukuda N, Izumi Y, Hatano M
Prostaglandins Leukot Med. 1986 Aug;23(2-3):289-302. doi: 10.1016/0262-1746(86)90196-4.
The effects of a calcium antagonist [Nicardipine hydrochloride (NH)] on the prostaglandin [prostaglandin E2 (PGE2), and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha)] and thromboxane B2 levels in the blood and urine were examined in 6 patients with essential hypertension following intravenous infusion of NH for 120 minutes. At the same time, the plasma renin activity (PRA), plasma aldosterone concentration (PAC), and plasma and urinary electrolyte levels were also determined. During NH administration, the blood pressure was significantly decreased (p less than 0.05) with an increased pulse rate (p less than 0.05). PRA was significantly increased after NH loading (p less than 0.05) but PAC showed no change. The plasma PGE2 and 6-keto-PGF1 alpha levels tended to increase slightly, while the blood thromboxane B2 level showed a decreasing tendency. The 6-keto-PGF1 alpha to thromboxane B2 ratio was significantly increased after NH loading as compared to the preloading ratio (p less than 0.05), and then returned to the preloading value at about 30 minutes after discontinuation of NH loading. The urinary excretions of PGE2, 6-keto-PGF1 alpha and thromboxane B2, PGE2 and 6-keto-PGF1 alpha tended to decrease after NH loading. In particular, the decrease in PGE2 was statistically significant (p less than 0.05). No change occurred in the urinary excretion of thromboxane B2. The above findings indicate that NH increased the plasma 6-keto-PGF1 alpha to thromboxane B2 ratio but decreased the urinary excretion of prostaglandins. In addition, the possible involvement of an enhanced 6-keto-PGF1 alpha/thromboxane B2 ratio in part of the hypotensive mechanism of NH is suggested.
对6例原发性高血压患者静脉输注盐酸尼卡地平（NH）120分钟，检测其血液和尿液中前列腺素[前列腺素E2（PGE2）和6-酮-前列腺素F1α（6-酮-PGF1α）]及血栓素B2水平的影响。同时，还测定了血浆肾素活性（PRA）、血浆醛固酮浓度（PAC）以及血浆和尿液电解质水平。在输注NH期间，血压显著下降（p<0.05），心率增加（p<0.05）。NH负荷后PRA显著升高（p<0.05），但PAC无变化。血浆PGE2和6-酮-PGF1α水平略有升高趋势，而血液中血栓素B2水平呈下降趋势。与负荷前相比，NH负荷后6-酮-PGF1α与血栓素B2的比值显著升高（p<0.05），在停止NH负荷后约30分钟恢复到负荷前水平。NH负荷后，尿液中PGE2、6-酮-PGF1α和血栓素B2、PGE2和6-酮-PGF1α的排泄量趋于减少。特别是PGE2的减少具有统计学意义（p<0.05）。血栓素B2的尿排泄量无变化。上述结果表明，NH增加了血浆6-酮-PGF1α与血栓素B2的比值，但降低了前列腺素的尿排泄量。此外，提示6-酮-PGF1α/血栓素B2比值升高可能部分参与了NH的降压机制。
