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静脉滴注联合经皮注射两性霉素 B 成功治疗儿童湿疹样毛霉菌病。

Successful Treatment of Eczema-Like Mucormycosis in a Child by Combination of Intravenous Drip and Percutaneous Injection Amphotericin B.

机构信息

Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

出版信息

Mycopathologia. 2019 Apr;184(2):309-313. doi: 10.1007/s11046-018-0273-6. Epub 2019 Jan 22.

Abstract

We report a case of eczema-like cutaneous mucormycosis caused by Rhizopus arrhizus. A 4-year-old child was presented to our hospital with a history of gradually enlarging papule and plaque in the periumbilical area for nearly 4 years since 2 weeks after his birth, and it has been misdiagnosed as eczema for nearly 3 years. Based on histopathology examination, the fungus culture test and DNA sequencing, it was revealed that R. arrhizus should be the responsible fungus for skin infection. The patient was successfully cured by combination of intravenous drip and percutaneous injection amphotericin B for nearly 3 months, and no recrudescence was seen during a follow-up of 6-month observation.

摘要

我们报告了一例由根毛霉引起的湿疹样皮肤毛霉病。一名 4 岁儿童因出生后 2 周内脐周出现逐渐增大的丘疹和斑块,近 4 年来就诊于我院,近 3 年来一直被误诊为湿疹。根据组织病理学检查、真菌培养试验和 DNA 测序结果,显示根毛霉应为皮肤感染的致病真菌。该患者经近 3 个月的静脉滴注和皮内注射两性霉素 B 联合治疗后痊愈,随访 6 个月未见复发。

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