Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria.
Clin Microbiol Infect. 2014 Jun;20 Suppl 6:60-6. doi: 10.1111/1469-0691.12566. Epub 2014 Feb 24.
Mucormycosis is an emerging fungal infection worldwide, with devastating disease symptoms and diverse clinical manifestations. The most important underlying risk factors are immunosuppression, poorly controlled diabetes, iron overload and major trauma. The aetiological agents involved in the disease have been re-classified due to changes in taxonomy and nomenclature, which also led to appropriately naming the disease 'mucormycosis'. This article shortly explains the new nomenclature, clinical manifestations and risk factors and focuses on putative virulence traits associated with mucormycosis, mainly in the group of diabetic ketoacidotic patients.
毛霉病是一种在全球范围内不断出现的真菌感染,具有破坏性的疾病症状和多种临床表现。最重要的潜在风险因素包括免疫抑制、未得到良好控制的糖尿病、铁过载和重大创伤。由于分类学和命名法的改变,参与该疾病的病原体已被重新分类,这也导致该疾病被恰当地命名为“毛霉病”。本文简要介绍了新的命名法、临床表现和风险因素,并重点介绍了与毛霉病相关的潜在毒力特征,主要是在糖尿病酮症酸中毒患者群体中。