体外联合多西环素和抗真菌药物治疗临床毛霉病病原体。
In vitro combination with doxycycline plus antifungals against clinical Mucorales pathogens.
机构信息
Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 210042, China.
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
出版信息
Braz J Microbiol. 2023 Dec;54(4):2597-2602. doi: 10.1007/s42770-023-01167-z. Epub 2023 Nov 7.
PURPOSE
Since systematic antifungals for mucormycosis showed variable MICs depending on strains, effective and safe antifungal therapy was still needed. This study is aimed to evaluate the in vitro activity of doxycycline combined with antifungal therapy against dominant Mucorales pathogens.
METHODS
Multidrug susceptibility testing was performed with doxycycline and antifungals, including itraconazole, posaconazole, and amphotericin, in 21 isolates of 8 dominant Mucorales pathogens.
RESULTS
The fractional inhibitory concentration index according to M38 showed one Rhizopus arrhizus isolate synergic (∑FICI = 0.375) and other isolates in addition (0.5 < ∑FICI < 4).
CONCLUSIONS
Doxycycline was found to have in vitro advantages in combined antifungal treatment over antifungals alone.
目的
由于系统性抗真菌药物治疗毛霉病的 MIC 值因菌株而异，因此仍需要有效的和安全的抗真菌治疗。本研究旨在评估多西环素联合抗真菌治疗对主要毛霉目病原体的体外活性。
方法
对 8 种主要毛霉目病原体的 21 株分离株进行多药敏感性试验，包括多西环素和抗真菌药物伊曲康唑、泊沙康唑和两性霉素。
结果
根据 M38 显示，1 株根毛霉分离株呈协同作用（∑FICI=0.375），其他分离株呈相加作用（0.5<∑FICI<4）。
结论
与单独使用抗真菌药物相比，多西环素在联合抗真菌治疗中有体外优势。
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