壳聚糖辅助不同二异氰酸酯制备的聚氨酯的细胞毒性、血液相容性和光谱研究评价。
Evaluation of cytotoxicity, hemocompatibility and spectral studies of chitosan assisted polyurethanes prepared with various diisocyanates.
机构信息
Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan.
Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
出版信息
Int J Biol Macromol. 2019 May 15;129:116-126. doi: 10.1016/j.ijbiomac.2019.01.084. Epub 2019 Jan 19.
In this research work cytocompatibility, mutagenicity, and hemolytic activity of chitosan-based polyurethanes (PUs) have been evaluated. The chitosan modified PUs were prepared by step-growth polymerization technique using various diisocyanates like isophorone diisocyanate (IPDI). 4,4'-methylenedicyclohexyl diisocyanate (HMDI), 2,4-toluene diisocyanate (TDI) and hexamethylene diisocyanate (HMDI) by reacting with hydroxyl-terminated polybutadiene (HTPB). Structural confirmation of prepared samples was done by FTIR-ATR and H NMR techniques. Chitosan bearing PU samples showed good hemocompatibility, non-mutagenic behavior and less or non-cytotoxic behavior with all the diisocyanates. Among all the diisocyanates, aromatic diisocyanate (TDI) showed less hemocompatibility, high mutagenicity, and more cytotoxicity. However, this still showed a better result than non-chitosan based sample. It is concluded that chitosan improved the biological behavior of PU samples.
在这项研究工作中，评估了壳聚糖基聚氨基甲酸酯（PUs）的细胞相容性、致突变性和溶血活性。壳聚糖改性的 PUs 通过逐步聚合技术制备，使用各种二异氰酸酯，如异佛尔酮二异氰酸酯（IPDI）、4,4'-亚甲基二环己基二异氰酸酯（HMDI）、2,4-甲苯二异氰酸酯（TDI）和己二异氰酸酯（HMDI），与端羟基聚丁二烯（HTPB）反应。通过傅里叶变换衰减全反射（FTIR-ATR）和核磁共振（H NMR）技术对制备的样品进行结构确认。壳聚糖基 PU 样品表现出良好的血液相容性、非致突变性和低细胞毒性或非细胞毒性，与所有二异氰酸酯均如此。在所有二异氰酸酯中，芳香族二异氰酸酯（TDI）表现出较低的血液相容性、较高的致突变性和更高的细胞毒性。然而，它的结果仍优于非壳聚糖基的样品。结果表明，壳聚糖改善了 PU 样品的生物学性能。
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