Zafar Kashif, Zia Khalid Mahmood, Alzhrani Rami M, Almalki Atiah H, Alshehri Sameer
Department of Applied Chemistry, Government College University, Faisalabad 38030, Pakistan.
Department of Chemistry, Government College University, Faisalabad 38030, Pakistan.
Polymers (Basel). 2022 May 20;14(10):2091. doi: 10.3390/polym14102091.
Many investigators have focused on the development of biocompatible polyurethanes by chemical reaction of functional groups contained in a spacer and introduced in the PU backbone or by a grafting method on graft polymerization of functional groups. In this study, alginate-based polyurethane (PU) composites were synthesized via step-growth polymerization by the reaction of hydroxyl-terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HMDI). The polymer chains were further extended with blends of 1,4-butanediol (1,4-BDO) and alginate (ALG) with different mole ratios. The structures of the prepared PU samples were elucidated with FTIR and H NMR spectroscopy. The crystallinity of the prepared samples was evaluated with the help of X-ray diffraction (XRD). The XRD results reveal that the crystallinity of the PU samples increases when the concentration of alginate increases. Thermogravimetric (TGA) results show that samples containing a higher amount of alginate possess higher thermal stability. ALG-based PU composite samples show more biocompatibility and less hemolytic activity. Mechanical properties, contact angle, and water absorption (%) were also greatly affected.
许多研究者通过在间隔基中所含官能团与引入聚氨酯主链中的官能团发生化学反应，或通过官能团接枝聚合的接枝方法，致力于生物相容性聚氨酯的开发。在本研究中，通过端羟基聚丁二烯（HTPB）与六亚甲基二异氰酸酯（HMDI）的逐步增长聚合反应合成了基于海藻酸钠的聚氨酯（PU）复合材料。聚合物链通过不同摩尔比的1,4 - 丁二醇（1,4 - BDO）和海藻酸钠（ALG）的混合物进一步扩链。用傅里叶变换红外光谱（FTIR）和氢核磁共振光谱（H NMR）对制备的PU样品的结构进行了阐明。借助X射线衍射（XRD）对制备样品的结晶度进行了评估。XRD结果表明，当海藻酸钠浓度增加时，PU样品的结晶度增加。热重分析（TGA）结果表明，含有较高含量海藻酸钠的样品具有更高的热稳定性。基于ALG的PU复合样品表现出更高的生物相容性和更低的溶血活性。力学性能、接触角和吸水率（%）也受到很大影响。
