Takaori K, Takeda T, Yamada H, Miura K, Yukimura T, Ikemoto F, Yamamoto K
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Jpn Circ J. 1988 Nov;52(11):1346-50. doi: 10.1253/jcj.52.1346.
Plasma immunoreactive renin was measured by sandwich radioimmunoassay, under various physiological and pathological conditions. Enzymatic activities of active renin and trypsin-activatable inactive renin were also measured. There was a significant correlation between plasma immunoreactive renin concentration (IRRC) and total (active plus inactive) renin concentration, as estimated by enzymatic activity. In plasma from normotensive volunteers and hypertensive patients, the IRRC were 279 +/- 37 pg/ml and 268 +/- 29 pg/ml, respectively. After the intravenous injection of furosemide, the plasma IRRC in normotensive volunteers increased significantly. IRRC was significantly higher in plasma from juvenile diabetics than in plasma from age-matched disease-free children. Thus, renin secretion in children with diabetes mellitus is increased.
在各种生理和病理条件下，采用夹心放射免疫分析法测定血浆免疫反应性肾素。同时还测定了活性肾素和胰蛋白酶可激活的无活性肾素的酶活性。通过酶活性估计，血浆免疫反应性肾素浓度（IRRC）与总（活性加无活性）肾素浓度之间存在显著相关性。在血压正常志愿者和高血压患者的血浆中，IRRC分别为279±37 pg/ml和268±29 pg/ml。静脉注射速尿后，血压正常志愿者的血浆IRRC显著升高。青少年糖尿病患者血浆中的IRRC显著高于年龄匹配的无病儿童血浆中的IRRC。因此，糖尿病儿童的肾素分泌增加。
