Li Wei, Xue Cong, Li Xinxin
State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Micromachines (Basel). 2019 Jan 21;10(1):74. doi: 10.3390/mi10010074.
A miniaturized thrombus dredger is proposed and developed in this study. The flexural resonance of the µ-resonator dredger is driven by a bulk-extensional magneto-elastic vibrator that is externally excited by alternating magnetic-field. With the fabricated prototype of the resonant dredger, a mice thrombus blocked in a simulated vessel is broken into micro-pieces, and the previously blocked vessel can recover to an unobstructed state within 1 h. A flow-rate ratio detection method is used to evaluate the thrombus-cleaning effectiveness. The comparison between the finite-element simulation and the experimental results validates the flow-rate ratio detection method. By optimally exciting the resonant dredger in its third resonant mode, the flow-rate ratio in the cleaned vessel increases by about 2.7 times compared with that in the partly blocked vessel, and the thrombus is smashed into micro-pieces.
本研究提出并开发了一种小型化血栓清除器。μ谐振器清除器的弯曲共振由体扩展磁弹性振动器驱动，该振动器由交变磁场外部激发。利用制造的共振清除器原型，将堵塞在模拟血管中的小鼠血栓破碎成微小碎片，先前堵塞的血管可在1小时内恢复畅通状态。采用流量比检测方法评估血栓清除效果。有限元模拟与实验结果的比较验证了流量比检测方法。通过在其第三共振模式下对共振清除器进行最佳激发，与部分堵塞血管相比，清除后血管中的流量比提高了约2.7倍，血栓被粉碎成微小碎片。
