Wang Z R, Ren L M, Li R, Guan X, Han Q M, Liu M L, Shao M, Zhang X, Chen S, Li Z G
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing100044, China.
Department of Rheumatology and Immunology, Tong Liao City Hospital, Tongliao 028000, China.
Zhonghua Yi Xue Za Zhi. 2019 Jan 15;99(3):178-182. doi: 10.3760/cma.j.issn.0376-2491.2019.03.005.
To analyze the 20-year survival rate, causes of death and predictors of systemic lupus erythematosus (SLE). A retrospective analysis was performed on 217 newly SLE patients who were diagnosed and treated by Peking University People's Hospital before June 2008. The clinical features and serologic data were studied. Survival rate of SLE patients over time, living conditions, causes of death and prognostic indicators of mortality were studied. The 10-, 15-and 20-year cumulative survival rate was 90.3%,88.1%and 79.6%, respectively. Infection and lupus encephalopathy were the main causes of death. Cox regression analysis revealed that lupus nephritis, neuropsychiatric systemic lupus erythematosus and age at the diagnosis were independent risk determinants for mortality. Prognosis of SLE remains to be improved. Early diagnosis, control of SLE organ damage and infection prevention are critical to improve survival of SLE patients.
分析系统性红斑狼疮（SLE）的20年生存率、死亡原因及预测因素。对2008年6月前在北京大学人民医院确诊并治疗的217例新发SLE患者进行回顾性分析。研究其临床特征及血清学数据。研究SLE患者的生存率随时间变化情况、生存状况、死亡原因及死亡的预后指标。SLE患者10年、15年及20年累积生存率分别为90.3%、88.1%和79.6%。感染和狼疮性脑病是主要死亡原因。Cox回归分析显示狼疮肾炎、神经精神性系统性红斑狼疮及诊断时年龄是死亡的独立风险决定因素。SLE的预后仍有待改善。早期诊断、控制SLE器官损害及预防感染对提高SLE患者生存率至关重要。
