Volozhin A I, Stupakov G P, Kazeĭkin V S
Kosm Biol Aviakosm Med. 1988 Jul-Aug;22(4):4-13.
This review surveys reported data and observations made by the present authors concerning the effect of real and simulated hypogravity on bones of man and various animals. Bone biomechanics and mechanisms of osteodystrophic changes in hypogravity are discussed. Based on published data about bone metabolism regulation, the concept of bone formation and degradation in normal gravity and hypogravity is advanced. The conclusion is made that hypogravity-induced changes obey regulation at different levels, with local mechanisms being predominant. It is emphasized that a detailed investigation of every component of this process may become an important contribution to space and clinical medicine.
本综述调查了作者们所报告的有关真实和模拟低重力对人类及各种动物骨骼影响的数据和观察结果。讨论了骨骼生物力学以及低重力下骨营养不良变化的机制。基于已发表的关于骨代谢调节的数据，提出了正常重力和低重力下骨形成与降解的概念。得出的结论是，低重力引起的变化在不同水平上受到调节，其中局部机制占主导。强调对这一过程的每个组成部分进行详细研究可能会对太空医学和临床医学做出重要贡献。
