Fawzy Manal S, Alshammari Mariam A, Alruwaili Ashwaq A, Alanazi Rehab T R, Alharbi Jewaher A M, Almasoud Abdulaziz Mohammed R, Alshammari Reem A, Toraih Eman A
Department of Biochemistry, Faculty of Medicine, Northern Border University, P.O. Box: 1321, Arar, Saudi Arabia.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
BMC Res Notes. 2019 Jan 22;12(1):51. doi: 10.1186/s13104-019-4088-4.
Foot complications are considered to be a devastating consequence of type 2 diabetes mellitus (T2DM), posing a major medical and economic burden. A prospective study was conducted at researchers' area "Northern area of Saudi Arabia" to determine the factors associated with diabetic foot (DF) among T2DM patients. Identifying the extent of this problem and the associated factors will enable the health providers to imply early preventive measurements.
Two hundred T2DM patients with/without DF (n = 100 for each group) were recruited. In total, the mean (SD) age of participants was 56 (± 12.2) years and nearly 70% of the patients were females. They showed a trend for higher frequency of impaired vibration perception, light touch pressure, proprioception and pain sensation than males in T2DM with DF. In univariate analysis, older age, long duration of diabetes and poor glycemic control reflected in high levels of HbA1c were significant factors associated with DF (OR = 4.1, 95% CI 2.3-7.4, P < 0.0001; OR = 6.5, 95% CI (4.9-9.3), P < 0.0001, and OR = 1.1, 95% CI (1.05-1.3), P = 0.002, respectively). Taken together, the current results could highlight the importance of epidemiological studies to raise the awareness of this important health care problem around the country.
足部并发症被认为是2型糖尿病（T2DM）的严重后果，带来了重大的医学和经济负担。在研究人员所在的沙特阿拉伯北部地区开展了一项前瞻性研究，以确定T2DM患者中与糖尿病足（DF）相关的因素。明确该问题的严重程度及相关因素将有助于医疗服务提供者采取早期预防措施。
招募了200例有/无DF的T2DM患者（每组100例）。参与者的平均（标准差）年龄为56（±12.2）岁，近70%的患者为女性。在患有DF的T2DM患者中，她们在振动觉减退、轻触觉压力、本体感觉和痛觉方面的频率趋势高于男性。单因素分析显示，年龄较大、糖尿病病程较长以及糖化血红蛋白（HbA1c）水平较高所反映的血糖控制不佳是与DF相关的显著因素（比值比[OR]=4.1，95%置信区间[CI] 2.3 - 7.4，P<0.0001；OR = 6.5，95% CI（4.9 - 9.3），P<0.0001，以及OR = 1.1，95% CI（1.05 - 1.3），P = 0.002）。总体而言，当前结果可凸显流行病学研究对于提高全国对这一重要医疗保健问题认识的重要性。
