Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Complement Ther Med. 2019 Feb;42:223-225. doi: 10.1016/j.ctim.2018.11.018. Epub 2018 Nov 20.
Analgesics, such as acetaminophen (APAP) and codeine (COD), are used to adulterate medicinal herbs and/or herbal supplements. This study evaluated the APAP and COD levels in 60 herbal supplement and/or herb-based medicine samples collected from apothecaries in Hamadan, Iran. The samples were analysed using a high-performance liquid chromatography (HPLC) system. The results showed that 15% of the samples contained 38900-165200 ng/g and 31.1-603.3 ng/g of APAP and COD, respectively. Due to the side-effects of analgesic drugs in human, control of these drugs is recommended in herbal supplements.
镇痛药，如对乙酰氨基酚（APAP）和可待因（COD），被用于掺假草药和/或草药补充剂。本研究评估了从伊朗哈马丹市的药店收集的 60 种草药补充剂和/或草药基药物样本中的 APAP 和 COD 水平。使用高效液相色谱（HPLC）系统对样品进行了分析。结果表明，15%的样品中分别含有 38900-165200ng/g 和 31.1-603.3ng/g 的 APAP 和 COD。由于镇痛药在人体中的副作用，建议在草药补充剂中控制这些药物。
