Strain J J
Biomedical Sciences Research Centre, University of Ulster, Jordanstown, Antrim, Northern Ireland.
Med Hypotheses. 1988 Dec;27(4):333-8. doi: 10.1016/0306-9877(88)90016-3.
Much emphasis has centred on the role of dietary calcium and calcium supplementation in the pathophysiology and prevention of osteoporosis. Yet there is accumulating evidence that current recommendations on preventive measures are at best of little value and are inconsistent with the available epidemiological data. It is proposed that more attention should be given to dietary trace elements, especially copper, in the aetiology of post-menopausal osteoporosis. Osteoporotic lesions attributable to copper deficiency have been described in both man and animals and the hypothesis that a mild dietary copper deficiency may be implicated in the onset and progression of osteoporosis is also consistent with the epidemiological evidence. Many western diets are low in copper but in addition milk and milk products are amongst the poorest sources of copper and lactose may interfere with copper metabolism. Current recommendations, therefore, for the prevention of osteoporosis may actually be detrimental to health.
人们一直非常重视膳食钙和补钙在骨质疏松症的病理生理学及预防中的作用。然而，越来越多的证据表明，目前关于预防措施的建议充其量价值不大，且与现有的流行病学数据不一致。有人提出，在绝经后骨质疏松症的病因学中，应更多关注膳食微量元素，尤其是铜。人类和动物中均已描述了因铜缺乏导致的骨质疏松性病变，并且轻度膳食铜缺乏可能与骨质疏松症的发生和发展有关这一假说也与流行病学证据相符。许多西方饮食中的铜含量较低，此外，牛奶及奶制品是铜含量最差的来源之一，而乳糖可能会干扰铜的代谢。因此，目前预防骨质疏松症的建议实际上可能对健康有害。
