Koga N, Kadota Y, Hatashita S, Hosaka Y, Sugimura J, Sakakibara T, Takagi S
Department of Neurosurgery, Tokyo Metropolitan Hiroo General Hospital.
No Shinkei Geka. 1988 Nov;16(12):1417-21.
We are reporting a rare case of clivus chordoma with fatal hemorrhage in the posterior fossa. A 38-year-old woman afflicted with sudden onset of severe headache and vomiting. On neurological examination, she was mildly lethargic. She had slight dysarthria and nystagmus, but no cranial nerve abnormalities. Craniogram revealed erosive changes in the right petrous bone. CT scan showed a massive intracerebellar hemorrhage and isodense mass in the sphenoid sinus, which were not enhanced by contrast medium. She became comatose and died 3 days later. No operation was performed. Autopsy revealed massive hemorrhage in the posterior fossa and yellowish, gelatinous tumor extending from the right clivus to the sphenoid sinus. Histological examination showed a chordoma. This case demonstrates that the hemorrhage associated with brain tumor, especially in posterior fossa, produces a significant sudden elevation of intracranial pressure and leads clinically to a rapid loss of consciousness and death soon after the onset.
我们报告一例罕见的斜坡脊索瘤伴后颅窝致命性出血的病例。一名38岁女性,突发严重头痛和呕吐。神经系统检查时,她略显嗜睡。有轻微构音障碍和眼球震颤,但无颅神经异常。颅骨X线片显示右侧岩骨有侵蚀性改变。CT扫描显示小脑内大量出血以及蝶窦内等密度肿块,增强造影剂后无强化。她陷入昏迷,3天后死亡。未进行手术。尸检发现后颅窝大量出血以及从右侧斜坡延伸至蝶窦的淡黄色、胶冻状肿瘤。组织学检查显示为脊索瘤。该病例表明,与脑肿瘤相关的出血,尤其是在后颅窝,会导致颅内压显著突然升高,并在临床上导致意识迅速丧失,发病后不久即死亡。