Kouhestani Somayeh, Zare Samad, Babaei Parvin
Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Physiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
J Menopausal Med. 2018 Dec;24(3):169-175. doi: 10.6118/jmm.2018.24.3.169. Epub 2018 Dec 31.
The rate of metabolic syndrome (MetS) in women diagnosed as they age is one of the main concerns of health cares. Recently new strategies used to prevent progressions of MetS toward the diagnosis of diabetes have focused on plant flavonoids. This study was aimed to investigate the beneficial effects of flavonoids fraction of () on MetS in ovariectomized (OVX) rats.
Twenty-four adult female Wistar rats, weighing 200 to 250 g, were divided into 3 groups: Sham surgery, OVX + Salin, or OVX + Flavonoid. Three weeks after ovariectomy, animals displayed MetS criteria received flavonoid injection (10 mg/kg, intraperitoneally) for 21 days. Then the body weight, body mass index, waist circumference, visceral fat, fasting blood glucose, serum insulin, lipid profiles and tumor necrosis factor-α (TNF-α) were measured.
Treatment with flavonoids fraction of significantly decreased serum level of insulin ( = 0.011), glucose ( = 0.024), TNF-α ( = 0.010), also MetS Z score ( = 0.020) and homeostasis model assessment of insulin resistance ( = 0.007). Lipid profiles and visceral fat showed insignificant reduction.
Flavonoids of attenuates some of the MetS components possibly via reduction in TNF-α inflammatory cytokine.
随着年龄增长被诊断出患有代谢综合征（MetS）的女性比例是医疗保健的主要关注点之一。最近，用于预防MetS进展为糖尿病的新策略集中在植物类黄酮上。本研究旨在调查（）类黄酮组分对去卵巢（OVX）大鼠MetS的有益作用。
将24只体重200至250克的成年雌性Wistar大鼠分为3组：假手术组、OVX + 生理盐水组或OVX + 类黄酮组。去卵巢3周后，符合MetS标准的动物接受类黄酮注射（10毫克/千克，腹腔注射），持续21天。然后测量体重、体重指数、腰围、内脏脂肪、空腹血糖、血清胰岛素、血脂谱和肿瘤坏死因子-α（TNF-α）。
用（）类黄酮组分治疗可显著降低血清胰岛素水平（P = 0.011）、血糖水平（P = 0.024）、TNF-α水平（P = 0.010），以及MetS Z评分（P = 0.020）和胰岛素抵抗的稳态模型评估（P = 0.007）。血脂谱和内脏脂肪的降低不显著。
（）类黄酮可能通过降低TNF-α炎性细胞因子来减轻一些MetS组分。
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