Tawfik Shady H, Mahmoud Bothaina F, Saad Mohamed I, Shehata Mona, Kamel Maher A, Helmy Madiha H
Department of Biochemistry, Medical Research Institute, Alexandria University, Egypt.
Department of Physiology, Medical Research Institute, Alexandria University, Egypt.
Biochem Res Int. 2015;2015:567945. doi: 10.1155/2015/567945. Epub 2015 Mar 5.
Type 2 diabetes mellitus (T2DM) is among the leading causes of death in postmenopausal women. The disruption of ovarian function may contribute to the incidence of T2DM. The purpose of this study was to investigate the effects of ovariectomy and T2DM on glucose and lipid homeostasis, perilipin levels in adipose tissues, as a lipolytic regulator, and levels of certain adipokines. Ovariectomized (OVX) rats were used as a model for postmenopausal women. The study was performed on sham, OVX, sham diabetic, and OVX diabetic female rats. The results indicated that ovariectomy alters adipose tissue metabolism through reducing perilipin content in white adipose tissue (WAT); however it has no effect on perilipin level in brown adipose tissue (BAT). OVX diabetic females suffer from serious metabolic disturbances, suggested by exacerbation of insulin resistance in terms of disrupted lipid profile, higher HOMA-IR, hyperinsulinemia, higher leptin, and lower adiponectin concentrations. These metabolic derangements may underlie the predisposition for cardiovascular disease in women after menopause. Therefore, for efficient treatment, the menopausal status of diabetic female should be addressed, and the order of events is of great importance because ovariectomy following development of diabetes has more serious complications compared to development of diabetes as result of menopause.
2型糖尿病（T2DM）是绝经后女性主要的死亡原因之一。卵巢功能紊乱可能导致T2DM的发生。本研究的目的是探讨卵巢切除术和T2DM对葡萄糖和脂质稳态、脂肪组织中作为脂解调节因子的周脂素水平以及某些脂肪因子水平的影响。将去卵巢（OVX）大鼠作为绝经后女性的模型。对假手术、OVX、假糖尿病和OVX糖尿病雌性大鼠进行了研究。结果表明，卵巢切除术通过降低白色脂肪组织（WAT）中的周脂素含量改变脂肪组织代谢；然而，它对棕色脂肪组织（BAT）中的周脂素水平没有影响。OVX糖尿病雌性大鼠存在严重的代谢紊乱，表现为脂质谱紊乱、更高的胰岛素抵抗指数（HOMA-IR）、高胰岛素血症、更高的瘦素和更低的脂联素浓度，提示胰岛素抵抗加剧。这些代谢紊乱可能是绝经后女性易患心血管疾病的基础。因此，为了有效治疗，应考虑糖尿病女性的绝经状态，而且事件发生的顺序非常重要，因为糖尿病发生后进行卵巢切除术比绝经导致糖尿病有更严重的并发症。
