电化学氧化 C-H/N-H 交叉偶联促进 C-N 键形成并伴随氢的析出。
Electrochemical oxidative C-H/N-H cross-coupling for C-N bond formation with hydrogen evolution.
机构信息
National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. China.
出版信息
Chem Commun (Camb). 2019 Feb 5;55(12):1809-1812. doi: 10.1039/c8cc09899a.
Under metal catalyst-free and exogenous-oxidant-free conditions, a series of C-3 aminated imidazo[1,2-a]pyridines were synthesized by electrochemical intermolecular oxidative C-H/N-H cross-coupling. Furthermore, by using a catalytic amount of ferrocene as the mediator, electrochemical intramolecular oxidative C-H/N-H cross-coupling for the synthesis of 10H-benzo[4,5]imidazo[1,2-a]indole derivatives has also been accomplished.
在无金属催化剂和外加氧化剂的条件下，通过电化学分子间氧化 C-H/N-H 交叉偶联反应合成了一系列 C-3 胺化的咪唑并[1,2-a]吡啶。此外，通过使用催化量的二茂铁作为介体，还实现了电化学分子内氧化 C-H/N-H 交叉偶联反应，用于合成 10H-苯并[4,5]咪唑并[1,2-a]吲哚衍生物。
Zotero 插件