呫吨与唑类的分子间阳极氧化交叉脱氢C(sp)-N键偶联反应
Intermolecular Anodic Oxidative Cross-Dehydrogenative C(sp)-N Bond-Coupling Reactions of Xanthenes with Azoles.
作者信息
Yang Yong-Zheng, Song Ren-Jie, Li Jin-Heng
机构信息
Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle , Nanchang Hangkong University , Nanchang 330063 , China.
State Key Laboratory of Chemo/Biosensing and Chemometrics , Hunan University , Changsha 410082 , China.
出版信息
Org Lett. 2019 May 3;21(9):3228-3231. doi: 10.1021/acs.orglett.9b00947. Epub 2019 Apr 18.
A new anode strategy for accessing xanthen-9-azoles via an electrochemical C(sp)-H/N-H cross-coupling of xanthenes with azoles is described. This reaction proceeds efficiently with a broad scope of both xanthenes and N-H-free azoles under metal- and additional oxidant-free conditions and represents a new access to direct incorporation of important N-heterocycle units into the resulting xanthenes.
描述了一种通过电化学使呫吨与唑类进行C(sp)-H/N-H交叉偶联来制备呫吨-9-唑类的新阳极策略。该反应在无金属和无额外氧化剂的条件下，对多种呫吨类和无N-H的唑类均能高效进行，为将重要的N-杂环单元直接引入所得呫吨类化合物提供了一种新方法。
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