Feng Qing, Bin Lu-Lu, Zhai Yan-Bing, Xu Min, Liu Zhi-Shun, Peng Wei-Na
Guang an'men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Xuanwu Hospital of Capital Medical University.
Zhongguo Zhen Jiu. 2019 Jan 12;39(1):3-8. doi: 10.13703/j.0255-2930.2019.01.001.
To observe the efficacy and safety of electroacupuncture (EA) on improving mini-mental state examination (MMSE) in patients with Alzheimer's disease (AD), and to evaluate the efficacy during follow-up visit.
Forty patients were randomly divided into a treatment group and a control group, 20 patients in each one (3 patients dropped off in the treatment group and 4 patients in the control group). The patients in the treatment group were treated with acupuncture at Baihui (GV 20), Fengfu (GV 16), Shenting (GV 24), Taiyang (EX-HN 5), Shangyintang (Extra 3) and Dazhong (KI 14); besides, EA was applied at Taiyang (EX-HN 5), Baihui (GV 20) and Shenting (GV 24) with dilatational wave, 10 Hz/50 Hz in frequency, 0.5 to 5.0 mA in intensity, once every two days, three treatments per week. The patients in the control group were treated with oral administration of donepezil hydrochloride tablets, once a day, taken before sleep. The treatment was given for 12 weeks in the two groups. The MMSE was evaluated before treatment, 12 weeks±3 days into treatment, and 24 weeks±7 days after treatment, respectively.
The difference of total score of MMSE before and 12 weeks±3 days into treatment was not significant between the two groups (>0.05); the total score of MMSE after treatment was higher than that before treatment (both <0.05); compared before treatment, the short-term memory score was increased in the treatment group (<0.05), and the increasing range was superior to that in the control group (<0.05). Compared before treatment, the total score of MMSE in the two groups were reduced 24 weeks ±7 days after treatment (both <0.05), and the reduction in the treatment group was less than that in the control group (<0.05); the differences of short-term memory score before and after treatment was significant between the two groups (<0.05). No adverse reaction occurred in the two groups.
The effect of EA on improving MMSE in patients with AD is similar to donepezil supported by evidence-based medicine. The effect of EA may have a certain continuous effect, and may have advantages in instantaneous memory. In addition, the EA is safe.
观察电针（EA）改善阿尔茨海默病（AD）患者简易精神状态检查表（MMSE）的疗效及安全性，并评估随访期间的疗效。
将40例患者随机分为治疗组和对照组，每组20例（治疗组脱落3例，对照组脱落4例）。治疗组患者针刺百会（GV 20）、风府（GV 16）、神庭（GV 24）、太阳（EX-HN 5）、上印堂（奇穴3）和大钟（KI 14）；此外，在太阳（EX-HN 5）、百会（GV 20）和神庭（GV 24）采用疏密波施加电针，频率为10Hz/50Hz，强度为0.5至5.0mA，每两天1次，每周治疗3次。对照组患者口服盐酸多奈哌齐片，每天1次，睡前服用。两组均治疗12周。分别在治疗前、治疗12周±3天和治疗后24周±7天评估MMSE。
两组治疗前与治疗12周±3天的MMSE总分差异无统计学意义（>0.05）；治疗后的MMSE总分高于治疗前（均<0.05）；与治疗前比较，治疗组的短期记忆评分升高（<0.05），升高幅度优于对照组（<0.05）。与治疗前比较，两组治疗后24周±7天的MMSE总分均降低（均<0.05），且治疗组降低幅度小于对照组（<0.
