Wu Jiawen, Teng Yunfei, Xie Yaming, Xing Shuangtao, Zhi Songsong
School of Music and Dance, Henan Normal University, Xinxiang, China.
School of Physical Education, Henan Normal University, Xinxiang, China.
Front Aging Neurosci. 2025 Mar 5;17:1541287. doi: 10.3389/fnagi.2025.1541287. eCollection 2025.
Alzheimer's disease (AD) is a progressive and debilitating neurodegenerative disorder that significantly impairs cognitive function and daily living abilities, representing a major public health challenge. Given the multifactorial nature of AD, effective therapeutic interventions targeting both cognitive and functional decline are critical. This study aimed to conduct a comprehensive comparison of the therapeutic effects of music therapy, acupuncture therapy, game therapy, cognitive training therapy, and exercise therapy on AD patients through a network meta-analysis. Randomized controlled trials (RCTs) published up until 2024 were systematically retrieved from multiple databases. Data were extracted, including the first author, publication year, country, total sample size, mean participant age, type and duration of intervention, and outcome measures such as the Mini-Mental State Examination, Activities of Daily Living, and Alzheimer's Disease Assessment Scale-Cognitive Subscale. Statistical analyses were performed using the RevMan 5.3 and Stata 17 software. The analysis included 52 RCTs with a total of 3,409 participants, offering a strong dataset. The results indicated that game therapy produced statistically significant improvements in mental state and daily living abilities, while acupuncture therapy yielded the most pronounced improvements in cognitive function among AD patients. Notably, the comparative efficacy of these interventions suggests that game therapy may offer short-term benefits, particularly for mental health and functional abilities, whereas acupuncture therapy demonstrated superior long-term cognitive enhancements. In conclusion, tailored physical and cognitive interventions such as game therapy and acupuncture therapy may hold significant potential in optimizing treatment outcomes for AD patients, with implications for both clinical practice and future research.
阿尔茨海默病（AD）是一种进行性且使人衰弱的神经退行性疾病，会显著损害认知功能和日常生活能力，是一项重大的公共卫生挑战。鉴于AD的多因素性质，针对认知和功能衰退的有效治疗干预至关重要。本研究旨在通过网络荟萃分析，全面比较音乐疗法、针灸疗法、游戏疗法、认知训练疗法和运动疗法对AD患者的治疗效果。从多个数据库系统检索截至2024年发表的随机对照试验（RCT）。提取的数据包括第一作者、发表年份、国家、总样本量、参与者平均年龄、干预类型和持续时间，以及简易精神状态检查表、日常生活活动能力和阿尔茨海默病评估量表 - 认知分量表等结局指标。使用RevMan 5.3和Stata 17软件进行统计分析。该分析纳入了52项RCT，共3409名参与者，提供了一个强大的数据集。结果表明，游戏疗法在精神状态和日常生活能力方面产生了具有统计学意义的改善，而针灸疗法在AD患者的认知功能方面产生了最显著的改善。值得注意的是，这些干预措施的比较疗效表明，游戏疗法可能带来短期益处，特别是对心理健康和功能能力而言，而针灸疗法则显示出卓越的长期认知增强效果。总之，诸如游戏疗法和针灸疗法等量身定制的身体和认知干预措施，在优化AD患者的治疗结局方面可能具有巨大潜力，对临床实践和未来研究均有启示意义。
