a College of Pharmacy, Shandong University , Jinan , China.
b College of Pharmacy, China Pharmaceutical University , Nanjing , China.
J Drug Target. 2019 Nov;27(9):917-931. doi: 10.1080/1061186X.2019.1572158. Epub 2019 Feb 6.
Curcumin (CUR), one of the major extracts of turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery. Nanopreparations could maintain the pharmacological effect of drugs, even the holistic effects of drug extracts. In addition, nanopreparations based on novel materials make it a reality to regulate the drug release rate according to the various environmental conditions. The therapeutic applications and novel investigated nanopreparations of CUR for prevention and treatment of various diseases, especially, cancer and inflammatory disorders are discussed in this review.
姜黄素（CUR）是姜黄的主要提取物之一，由于其具有抗癌、抗菌、抗溃疡、抗抑郁、抗炎和伤口愈合作用，因此备受关注。然而，其应用的一个主要障碍在于其内在的低水溶性、不稳定性和半衰期短。为了克服这些障碍，已经采用了不同的策略，如制备纳米制剂和开发稳定且亲水性的衍生物以及联合药物递送。纳米制剂可以保持药物的药理作用，甚至是药物提取物的整体作用。此外，基于新型材料的纳米制剂使根据各种环境条件调节药物释放速率成为可能。本文综述了 CUR 用于预防和治疗各种疾病（特别是癌症和炎症性疾病）的治疗应用和新型研究纳米制剂。
