Shen Qian, Pan Xue, Li Yi, Li Junchen, Zhang Chuanlong, Jiang Xiaochen, Liu Fudong, Pang Bo
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Pharmacol. 2023 Jul 7;14:1220983. doi: 10.3389/fphar.2023.1220983. eCollection 2023.
Curcumin is a natural active ingredient from traditional Chinese medicine (TCM) that has multi-target characteristics to exert extensive pharmacological activities and thus has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. As an important class of membranous organelles in the intracellular membrane system, lysosomes are involved in biological processes such as programmed cell death, cell metabolism, and immune regulation, thus affecting tumor initiation and progression. It has been shown that curcumin can modulate lysosomal function through the aforementioned pathways, thereby affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function. This review briefly elaborated the regulatory mechanisms of lysosome biogenesis and summarized curcumin-related studies with its anti-tumor effect, providing a reference for the clinical application of curcumin and anti-tumor research targeting lysosomes.
姜黄素是一种源自中药的天然活性成分，具有多靶点特性，可发挥广泛的药理活性，因此已应用于治疗各种疾病，如癌症、心血管疾病、神经系统疾病和自身免疫性疾病。作为细胞内膜系统中一类重要的膜性细胞器，溶酶体参与程序性细胞死亡、细胞代谢和免疫调节等生物学过程，从而影响肿瘤的发生和进展。研究表明，姜黄素可通过上述途径调节溶酶体功能，进而影响肿瘤的增殖、侵袭、转移、耐药性和免疫功能。本文综述简要阐述了溶酶体生物发生的调控机制，并总结了姜黄素相关的抗肿瘤作用研究，为姜黄素的临床应用及针对溶酶体的抗肿瘤研究提供参考。
