基因多态性与血管紧张素转换酶抑制剂所致咳嗽之间的关联：一项系统评价和荟萃分析
Association between genetic polymorphisms and angiotensin-converting enzyme inhibitor-induced cough: a systematic review and meta-analysis.
作者信息
Mu Guangyan, Xiang Qian, Zhou Shuang, Xie Qiufen, Liu Zhiyan, Zhang Zhuo, Cui Yimin
机构信息
Department of Pharmacy, Peking University First Hospital, 6# Dahongluochang Street, Xicheng District, Beijing, 100034, PR China.
出版信息
Pharmacogenomics. 2019 Feb;20(3):189-212. doi: 10.2217/pgs-2018-0157. Epub 2019 Jan 23.
AIM
Genetic polymorphisms may influence the incidence of angiotensin-converting enzyme (ACE) inhibitor-induced cough. This study aims to investigate this association.
METHODS
Ten electronic databases and PharmGKB were systematically searched. Pooled odds ratio values and their 95% CI were used to assess the association, using the random-effects model.
RESULTS
A total of 26 studies were included in the review, 17 of them were included from two separated meta-analysis (ACE I/D or BDKRB2-58T/C). Significant association was found between ACE I/D I carriers (ACE gene insertion) and ACE inhibitor-induced cough, showing racial and age differences.
CONCLUSION
This study demonstrated that ACE I/D but not BDKRB2-58T/C polymorphism could be a predictor for the risk of ACE inhibitor-induced cough, especially in east Asians and the aged.
目的
基因多态性可能影响血管紧张素转换酶（ACE）抑制剂所致咳嗽的发生率。本研究旨在调查这种关联。
方法
系统检索了10个电子数据库和PharmGKB。采用随机效应模型，合并比值比及其95%置信区间来评估这种关联。
结果
本综述共纳入26项研究，其中17项来自两项独立的荟萃分析（ACE I/D或BDKRB2 - 58T/C）。发现ACE I/D I携带者（ACE基因插入）与ACE抑制剂所致咳嗽之间存在显著关联，呈现种族和年龄差异。
结论
本研究表明，ACE I/D而非BDKRB2 - 58T/C多态性可能是ACE抑制剂所致咳嗽风险的一个预测指标，尤其是在东亚人和老年人中。
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