沙鼠和棉鼠对魏氏棘唇线虫和卡里尼丝虫（线虫纲：丝虫总科）微丝蚴的同源和交叉反应免疫应答。
Homologous and crossreacting immune response of the jird and cotton rat against microfilariae of Dipetalonema viteae and Litomosoides carinii (Nematoda: Filarioidea).
作者信息
Bayer M, Wenk P
机构信息
Institute of Tropical Medicine, University of Tübingen, FRG.
出版信息
Trop Med Parasitol. 1988 Dec;39(4):304-8.
Consecutive injections of microfilariae of L. carinii and D. viteae were carried out in the homologous or heterologous sequence into the corresponding natural or into the experimental hosts. Microfilariae of D. viteae are imunogenic in Sigmodon specifically and crossreacting as well. However, in the natural host, Meriones, they are doubtlessly tolerogenic. The sojourn and level of microfilaraemia are prolonged resp. higher when living D. viteae-Mf are injected s.c. followed by an i.v. injection. However, freeze-killed microfilariae of D. viteae are immunogenic in Meriones. Obviously the two filarial worms living in small mammals realize the balance with their natural hosts in quite a different manner. Which one of the two possibilities, or if one of them at all, reflects the relationship in human pathogenic filariae remains open.
将卡氏肺孢子虫和维氏丝虫的微丝蚴按同源或异源顺序连续注射到相应的天然宿主或实验宿主中。维氏丝虫的微丝蚴在棉鼠中具有特异性免疫原性，也会发生交叉反应。然而，在天然宿主子午沙鼠中，它们无疑具有耐受性。当皮下注射活的维氏丝虫微丝蚴后再静脉注射时，微丝蚴血症的持续时间和水平会延长或升高。然而，经冷冻杀死的维氏丝虫微丝蚴在子午沙鼠中具有免疫原性。显然，生活在小型哺乳动物体内的这两种丝虫与它们的天然宿主实现平衡的方式截然不同。这两种可能性中的哪一种，或者是否其中之一反映了人类致病丝虫的关系，仍有待确定。
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