Weiss N
Acta Trop. 1978 Jun;35(2):137-50.
The course of a primary infection with Dipetalonema viteae was studied in one randomly bred and in one inbred strain of hamster. Worm recovery and the duration and intensity of the microfilaraemia were analyzed and related to the humoral immune response of the host by using the indirect immunofluorescent antibody test on frozen sections of female worms, on eggs and on intact microfilariae. The inbred strain showed a greater susceptibility to the parasite. This was evidenced by high worm recovery and prolonged microfilaraemia. The duration of microfilaraemia did not depend on the number of recovered female worms. Most of the randomly bred hamsters suppressed microfilaraemia by week 30 post infection whereas some hamsters of the inbred strain were still microfilaraemic. Splenectomy prior to infection did not affect the duration of microfilaraemia. Antibodies to the cuticle of microfilariae always appeared in the sera after immunity to circulating microfilariae had been built up.
在一个随机繁殖的仓鼠品系和一个近交系仓鼠中研究了感染魏氏棘唇线虫的原发性感染过程。分析了蠕虫回收率、微丝蚴血症的持续时间和强度，并通过对雌虫、虫卵和完整微丝蚴的冰冻切片进行间接免疫荧光抗体试验，将其与宿主的体液免疫反应相关联。近交系仓鼠对该寄生虫表现出更高的易感性。这通过高蠕虫回收率和延长的微丝蚴血症得到证明。微丝蚴血症的持续时间并不取决于回收的雌虫数量。大多数随机繁殖的仓鼠在感染后第30周抑制了微丝蚴血症，而一些近交系仓鼠仍有微丝蚴血症。感染前进行脾切除并不影响微丝蚴血症的持续时间。在对循环微丝蚴产生免疫力后，血清中总是会出现针对微丝蚴角质层的抗体。
