Department of Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146 , United States.
Department of Biology , University of Miami , 1301 Memorial Drive , Coral Gables, Florida 33146 , United States.
Langmuir. 2019 Feb 19;35(7):2814-2820. doi: 10.1021/acs.langmuir.8b03505. Epub 2019 Feb 6.
Fumonisin B1 (FB1), the most abundant component of the fumonisin family, is highly responsible for fungal infections. In this paper, our main aim is to study the surface chemistry and spectroscopic properties of the FB1 molecule and observe the impact of green LED light on the FB1 Langmuir monolayer. From the surface chemistry and spectroscopic studies, we found that the FB1 molecule forms a self-assembled Langmuir monolayer which is sufficient to mimic its interaction with the corneal tissues. The irradiation of green LED light on the FB1 Langmuir monolayer showed the degradation of the FB1 when compared to that in the absence of light. This observation reveals that FB1 molecules lose their tendency to stay as a Langmuir monolayer. The degradation observed on the interface was compared with the bulk phase of FB1. The bulk phase observation also indicated the degradation tendency which reinforced the observed interfacial property of FB1.
伏马菌素 B1（FB1）是伏马菌素家族中含量最丰富的成分，是导致真菌感染的主要原因。在本文中，我们的主要目的是研究 FB1 分子的表面化学和光谱特性，并观察绿光 LED 光对 FB1 朗缪尔单层的影响。从表面化学和光谱研究中，我们发现 FB1 分子形成了一个自组装的朗缪尔单层，足以模拟其与角膜组织的相互作用。与没有光照相比，绿光 LED 光照射在 FB1 朗缪尔单层上会导致 FB1 的降解。这一观察结果表明，FB1 分子失去了保持朗缪尔单层的趋势。在界面上观察到的降解与 FB1 的体相进行了比较。对体相的观察也表明了降解的趋势，这加强了对 FB1 界面性质的观察。
