Maxillofacial surgeon, Hospital General Universitario Albacete, Albacete, Spain.
Maxillofacial surgeon, Hospital General Universitario Virgen de las Nieves, Granada, Spain.
J Stomatol Oral Maxillofac Surg. 2022 Nov;123(6):e808-e813. doi: 10.1016/j.jormas.2022.07.005. Epub 2022 Jul 8.
Unlike other types of cancers, the prognostic value of histological tumor grade is not well determined for oral squamous cell carcinoma (OSCC). This study therefore aimed to evaluate the impact of tumor differentiation on prognosis and overall survival of patients affected by squamous cell carcinoma of the oral cavity.
A retrospective analysis was conducted using the records of patients diagnosed with squamous cell carcinoma of the oral cavity between 2010 and 2015. The study included 162 patients treated with a tumorectomy and selective neck dissection. The influence of histological tumor grade on several prognostic factors such as T-Stage, N-stage, recurrence rate, perineural invasion, vascular invasion, surgical margins, and overall survival was analyzed.
Histological grade strongly correlated with N-stage, recurrence rate, perineural invasion, vascular invasion, surgical margins, and overall survival. Overall survival was 71.6% in patients with well-differentiated tumors and 43.2% in those with moderately and poorly differentiated tumors.
Histological grade represents an important prognostic factor for OSCC. Therefore, various treatment strategies based on this histological parameter could improve the overall survival rate of patients affected by oral squamous cell carcinoma.
与其他类型的癌症不同，口腔鳞状细胞癌（OSCC）的组织学肿瘤分级的预后价值尚未确定。因此，本研究旨在评估肿瘤分化对口腔鳞状细胞癌患者预后和总生存率的影响。
对 2010 年至 2015 年间诊断为口腔鳞状细胞癌的患者的记录进行了回顾性分析。该研究纳入了 162 例接受肿瘤切除术和选择性颈部解剖的患者。分析了组织学肿瘤分级对 T 分期、N 分期、复发率、神经周围侵犯、血管侵犯、手术切缘和总生存率等多个预后因素的影响。
组织学分级与 N 分期、复发率、神经周围侵犯、血管侵犯、手术切缘和总生存率密切相关。分化良好的肿瘤患者的总生存率为 71.6%，而中、低分化肿瘤患者的总生存率为 43.2%。
组织学分级是 OSCC 的一个重要预后因素。因此，基于该组织学参数的各种治疗策略可以提高口腔鳞状细胞癌患者的总生存率。
