Ohsedo Yutaka
Advanced Materials Research Laboratory, Collaborative Research Division, Art, Science and Technology Center for Cooperative Research, Kyushu University, 6-1 Kasuga-koen, Kasuga-city, Fukuoka 816-8580, Japan.
Comprehensive Research Organization, Fukuoka Institute of Technology, 3-30-1, Wajiro-Higashi, Higashi-ku, Fukuoka 811-0295, Japan.
Gels. 2016 Apr 1;2(2):13. doi: 10.3390/gels2020013.
Ointments have been widely used as an efficient means of transdermal drug application for centuries. In order to create ointments suitable for various new medicinal drugs, the creation of ointment base materials, such as gels, has attracted much research attention in this decade. On the other hand, the chemical tuning of low-molecular-weight gelators (LMWGs) has been increasingly studied for two decades because LMWGs can be tailored for different purposes by molecular design and modification. In this review, several series of studies related to the creation of ointment base materials with enhanced properties using existing and newly-created LMWGs are summarized.
几个世纪以来,软膏一直作为一种有效的透皮给药方式被广泛使用。为了制备适用于各种新型药物的软膏,诸如凝胶等软膏基质材料的研发在过去十年中受到了广泛的研究关注。另一方面,二十年来,低分子量凝胶剂(LMWGs)的化学调控研究日益增多,因为可以通过分子设计和修饰对低分子量凝胶剂进行定制以满足不同用途。在本综述中,总结了一系列使用现有和新制备的低分子量凝胶剂制备具有增强性能的软膏基质材料的相关研究。