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两例骨关节毛霉感染病例:诊断与处理难题

Two cases of Osteoarticular Mucor menace: A diagnostic and management conundrum.

作者信息

Bhatt Manasvini, Soneja Manish, Fazal Farhan, Vyas Surabhi, Kumar Prabhat, Jorwal Pankaj, Raj Upendra, Sachdev Janya, Singh Gagandeep, Xess Immaculata, Alam Shah, Biswas Ashutosh

机构信息

Department of Medicine, All India Institute of Medical Sciences.

Department of Radiodiagnosis, All India Institute of Medical Sciences.

出版信息

Drug Discov Ther. 2018;12(6):374-378. doi: 10.5582/ddt.2018.01064.

Abstract

Mucormycosis is an uncommon aggressive fungal infection usually seen in immunocompromised hosts or patients with burns and trauma. The common presentations include rhino-orbital-cerebral and pulmonary involvement. Osteoarticular involvement is a rare presentation of this disease. We present two cases of osteoarticular mucormycosis of pelvis and long bones of the lower limb, one in a patient with burn injury and other one in a patient with chronic granulomatous disease, hitherto a rarely reported association. Delayed diagnosis in a setting where tuberculosis is a common cause of chronic osteomyelitis, challenges in medical and surgical management of these patients are discussed in this report.

摘要

毛霉病是一种罕见的侵袭性真菌感染,通常见于免疫功能低下的宿主或烧伤及创伤患者。常见表现包括鼻眶脑和肺部受累。骨关节炎受累是该疾病的罕见表现。我们报告两例骨盆和下肢长骨的骨关节炎性毛霉病病例,一例发生在烧伤患者中,另一例发生在慢性肉芽肿病患者中,这种关联迄今鲜有报道。在结核病是慢性骨髓炎常见病因的情况下出现延迟诊断,本报告讨论了这些患者在医疗和手术管理方面面临的挑战。

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