Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.
作者信息
Nabinger Sarah C, Chen Sisi, Gao Rui, Yao Chonghua, Kobayashi Michihiro, Vemula Sasidhar, Fahey Aidan C, Wang Christine, Daniels Cecil, Boswell H Scott, Sandusky George E, Mayo Lindsey D, Kapur Reuben, Liu Yan
机构信息
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
出版信息
Leukemia. 2019 Jun;33(6):1535-1539. doi: 10.1038/s41375-019-0377-0. Epub 2019 Jan 23.
Abstract
摘要
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本文引用的文献
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Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53.基因毒性应激促进表达突变型p53的造血干细胞的克隆性扩增。
Leukemia. 2018 Mar;32(3):850-854. doi: 10.1038/leu.2017.325. Epub 2017 Nov 16.
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Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.成人急性髓系白血病中p53蛋白的功能失调多样性：对诊断检查和治疗的启示
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Molecular therapy for acute myeloid leukaemia.急性髓系白血病的分子治疗
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Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.初诊及复发时伴有FLT3-ITD的急性髓系白血病体细胞突变分析
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Drugging the p53 pathway: understanding the route to clinical efficacy.靶向 p53 通路：探索通往临床疗效的途径。
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6
ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia.ASXL1、TP53和IKZF3突变存在于慢性髓性白血病的慢性期和急变期。
Blood Cancer J. 2013 Nov 8;3(11):e157. doi: 10.1038/bcj.2013.54.
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Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.靶向 FMS 样酪氨酸激酶 3 治疗急性髓系白血病。
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TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.急性髓系白血病伴复杂核型中 TP53 改变与特定拷贝数改变、单体核型和不良预后相关。
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Targeting leukemic stem cells by breaking their dormancy.通过打破白血病干细胞休眠来靶向它们。
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Nat Rev Cancer. 2009 Oct;9(10):701-13. doi: 10.1038/nrc2693. Epub 2009 Aug 20.
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