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ASXL1, TP53 and IKZF3 mutations are present in the chronic phase and blast crisis of chronic myeloid leukemia.

作者信息

Menezes J, Salgado R N, Acquadro F, Gómez-López G, Carralero M C, Barroso A, Mercadillo F, Espinosa-Hevia L, Talavera-Casañas J G, Pisano D G, Alvarez S, Cigudosa J C

机构信息

Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center-CNIO, Madrid, Spain.

出版信息

Blood Cancer J. 2013 Nov 8;3(11):e157. doi: 10.1038/bcj.2013.54.

DOI:10.1038/bcj.2013.54
PMID:24212482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3880437/
Abstract
摘要

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RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses.RUbioSeq：一套并行管道，用于自动化外显子变异和亚硫酸氢盐测序分析。
Bioinformatics. 2013 Jul 1;29(13):1687-9. doi: 10.1093/bioinformatics/btt203. Epub 2013 Apr 28.
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NPM1 mutations occur rarely or not at all in chronic myeloid leukaemia patients in chronic phase or blast crisis.
Leukemia. 2013 Feb;27(2):489-90. doi: 10.1038/leu.2012.193. Epub 2012 Jul 13.
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Chronic myeloid leukemia: clinical impact of BCR-ABL1 mutations and other lesions associated with disease progression.慢性髓细胞白血病：BCR-ABL1 突变及其他与疾病进展相关的病变的临床影响。
慢性粒细胞白血病中除BCR-ABL之外的体细胞突变谱分析的意义：一项针对印度人群的回顾性研究
Indian J Hematol Blood Transfus. 2025 Jan;41(1):10-22. doi: 10.1007/s12288-024-01808-9. Epub 2024 Jun 21.
4
Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression.IKZF1无序区域中保守的螺旋基序介导NuRD相互作用和转录抑制。
Blood. 2025 Jan 23;145(4):422-437. doi: 10.1182/blood.2024024787.
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Therapeutic options for chronic myeloid leukemia following the failure of second-generation tyrosine kinase inhibitor therapy.第二代酪氨酸激酶抑制剂治疗失败后慢性髓性白血病的治疗选择
Front Oncol. 2024 Jul 29;14:1446517. doi: 10.3389/fonc.2024.1446517. eCollection 2024.
6
An Update on the Management of Advanced Phase Chronic Myeloid Leukemia.晚期慢性髓系白血病治疗的最新进展
Curr Hematol Malig Rep. 2023 Dec;18(6):234-242. doi: 10.1007/s11899-023-00709-4. Epub 2023 Aug 31.
7
Targeted Next-Generation Sequencing Identifies Additional Mutations Other than in Chronic Myeloid Leukemia Patients: A Chinese Monocentric Retrospective Study.靶向二代测序鉴定慢性髓性白血病患者中除 之外的其他突变：一项中国单中心回顾性研究
Cancers (Basel). 2022 Nov 23;14(23):5752. doi: 10.3390/cancers14235752.
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A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases.一项针对处于急变期的慢性髓性白血病（BC-CML）患者的深度测序研究发现，76.9%的病例存在突变。
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