Sánchez-Infantes David, Cereijo Rubén, Sebastiani Giorgia, Pérez-Cruz Miriam, Villarroya Francesc, Ibáñez Lourdes
Institut de Recerca Pediàtrica Hospital Sant Joan de Déu (IRP-HSJD), University of Barcelona, 08950 Esplugues, Barcelona, Spain.
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain.
Int J Endocrinol. 2018 Dec 23;2018:7562702. doi: 10.1155/2018/7562702. eCollection 2018.
Nerve growth factor (NGF) plays a key role in neuroprotection and developmental maturity. We assessed longitudinally the circulating concentrations of NGF in term healthy human newborns and infants as well as their association with prenatal growth and early postnatal feeding patterns.
Circulating NGF and anthropometric measures (weight, length, body mass index, and ponderal index) were assessed longitudinally-at birth and at age 4 months-in 86 term infants born appropriate (AGA), small (SGA), or large for gestational age (LGA).
Cord blood NGF levels in SGA newborns were higher than those in AGA newborns (1.41 ± 0.2 pg/mL vs. 0.66 ± 0.1 pg/mL; = 0.02) and not different from those in LGA neonates (0.79 ± 0.2 pg/mL). At age 4 months, SGA-breastfed infants showed the highest NGF concentrations ( = 0.02 and = 0.01 vs. AGA and SGA-formula-fed infants, respectively), while LGA infants depicted a marginal increase. NGF levels in cord blood correlated negatively with the ponderal index at birth ( = -0.36; = 0.0008).
Circulating NGF is related to both prenatal growth and early postnatal nutrition. The maintenance of increased NGF concentrations in SGA-breastfed infants at age 4 months might be a potential mechanism to counterbalance potential risks for developing cognitive and psychomotor disadvantages.
神经生长因子（NGF）在神经保护和发育成熟中起关键作用。我们纵向评估了足月儿健康新生儿和婴儿体内NGF的循环浓度，以及它们与产前生长和出生后早期喂养模式的关联。
对86名适于胎龄（AGA）、小于胎龄（SGA）或大于胎龄（LGA）的足月儿在出生时和4个月大时纵向评估循环NGF和人体测量指标（体重、身长、体重指数和 ponderal指数）。
SGA新生儿的脐血NGF水平高于AGA新生儿（1.41±0.2 pg/mL对0.66±0.1 pg/mL；P = 0.02），与LGA新生儿的水平无差异（0.79±0.2 pg/mL）。在4个月大时，SGA母乳喂养的婴儿NGF浓度最高（分别与AGA和SGA配方奶喂养的婴儿相比，P = 0.02和P = 0.01），而LGA婴儿有轻微升高。脐血中的NGF水平与出生时的ponderal指数呈负相关（r = -0.36；P = 0.0008）。
循环NGF与产前生长和出生后早期营养均有关。4个月大时SGA母乳喂养婴儿中NGF浓度升高的维持可能是抵消发展为认知和心理运动缺陷潜在风险的一种潜在机制。
