Department of Otolaryngology, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Head Neck. 2019 Jun;41(6):1846-1853. doi: 10.1002/hed.25622. Epub 2019 Jan 23.
This study evaluated the prognostic role of Fluorine 18-fluorodeoxyglucose positron emission tomography/CT ( F-FDG PET/CT) parameters quantitatively measured in patients with recurrent oral cavity cancer.
Cox proportional hazards regression analyses were used to assess the associations between quantitative F-FDG PET/CT parameters and other clinicopathological factors and progression-free survival (PFS) and overall survival (OS).
All of the F-FDG PET parameters (SUV , SUV , SUV , metabolic tumor volume [MTV], and total lesion glycolysis [TLG]) were significantly associated with poor PFS and OS outcomes after salvage treatment (P < .01). In multivariate analyses, Karnofsky performance score, recurrence site, MTV, and TLG were independent variables predictive of both PFS and OS (P < .05). High MTV (>8.8 mL) or TLG (>29.4 g) values at recurrent lesions were associated with >5-fold increased risk for tumor progression and mortality after salvage surgery.
The PET parameters of MTV and TLG measured at recurrent lesions may predict tumor progression and survival after salvage treatment.
This study examined the role of F-FDG PET/CT at recurrent staging for predicting tumor progression and survival in 71 consecutive patients with recurrent oral cavity squamous cell carcinomas. Of F-FDG parameters, metabolic tumor volume and total lesion glycolysis were independent factors predictive of tumor progression and survival after salvage treatment.
本研究评估了氟-18-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）在复发性口腔癌患者中定量测量的预后价值。
采用 Cox 比例风险回归分析评估定量 F-FDG PET/CT 参数与其他临床病理因素以及无进展生存期（PFS）和总生存期（OS）之间的关系。
所有 F-FDG PET 参数（SUV max 、SUV mean 、SUV peak 、代谢肿瘤体积[MTV]和总病变糖酵解[TLG]）均与挽救治疗后 PFS 和 OS 结局较差显著相关（P<0.01）。在多变量分析中，Karnofsky 表现评分、复发部位、MTV 和 TLG 是 PFS 和 OS 的独立预测变量（P<0.05）。复发病灶的 MTV（>8.8 mL）或 TLG（>29.4 g）值较高与挽救手术后肿瘤进展和死亡率增加 5 倍以上相关。
复发病灶测量的 MTV 和 TLG PET 参数可预测挽救治疗后肿瘤的进展和生存。
本研究检查了在 71 例复发性口腔鳞状细胞癌患者中，复发期 F-FDG PET/CT 对预测肿瘤进展和生存的作用。在 F-FDG 参数中，代谢肿瘤体积和总病变糖酵解是挽救治疗后肿瘤进展和生存的独立预测因素。
