通过铱催化的级联 C-H 酰胺化和分子内氮杂迈克尔加成合成二氢喹啉酮。
Synthesis of dihydroquinolinones via iridium-catalyzed cascade C-H amidation and intramolecular aza-Michael addition.
机构信息
School of Chemical and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
出版信息
Chem Commun (Camb). 2019 Feb 7;55(13):1915-1918. doi: 10.1039/c8cc09751h.
PMID:30676590
Abstract
An iridium-catalyzed annulation of chalcones with sulfonyl azides via cascade C-H amidation and intramolecular aza-Michael addition was developed, affording a variety of 2-aryl-2,3-dihydro-4-quinolones in moderate to good yields. This reaction features easy operation, readily available starting materials, and the cascade formation of two C-N bonds in one pot.
摘要
发展了一种铱催化的查尔酮与磺酰叠氮化物的串联 C-H 酰胺化和分子内氮杂 Michael 加成反应，以中等至良好的收率得到了多种 2-芳基-2,3-二氢-4-喹诺酮类化合物。该反应具有操作简单、原料易得以及一锅法中两个 C-N 键的串联形成等特点。
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